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Endocarditis
Reviewed by Medicinsk Expert•Last updated: 2026-10-22•Blood Heart Circulation

Endocarditis

Endocarditis is a rare but life-threatening inflammation of the heart's inner lining, typically caused by an infection.

Overview

Endocarditis, sometimes called infective endocarditis, is an inflammation of the lining inside your heart's chambers and valves, known as the endocardium. It occurs when germs enter the bloodstream and travel to the heart, where they attach to the lining or become trapped in the valves. If left untreated, the resulting infection can cause significant heart damage.

Causes

Most cases of endocarditis are caused by bacterial infections. Bacteria normally found in the mouth, on the skin, or in other parts of the body can enter the bloodstream through injuries like cuts or scrapes, as well as through dental work or certain surgeries. In rarer cases, fungal infections—such as yeast—can cause endocarditis, typically in individuals with weakened immune systems, including those with HIV.

Risk Factors

While endocarditis is rare in healthy individuals, your risk may be higher if you:

  • Have certain heart conditions: Damaged or abnormal heart tissue can trap germs more easily. This includes heart valve disease, certain congenital heart defects, the presence of a pacemaker or implantable defibrillator, or a heart valve replacement.
  • Are older: Age-related changes to heart valves, such as mitral valve prolapse or calcium deposits in the aortic valve, create sites for germs to attach.
  • Inject illegal drugs: Unclean needles can introduce bacteria into the bloodstream.
  • Have a weakened immune system.
  • Have poor dental health: Neglecting teeth and gums makes it easier for germs to enter the bloodstream.
  • Have a long-term central venous line: A tube placed in a large vein for medical treatment over weeks or months.
  • Have a history of endocarditis: Previous infection can damage heart tissue, increasing the risk of recurrence.

Symptoms

Symptoms can vary significantly between individuals and may appear suddenly or develop slowly. They include:

  • Fever and chills
  • New or worsening heart murmur
  • Chest pain
  • Cough
  • Muscle, joint, and back pain
  • Night sweats
  • Shortness of breath
  • Skin changes, such as broken blood vessels, painful red or purple bumps, or painless flat red spots on the palms or soles.

Complications

Infected clumps of germs and blood cells can break off and travel through the bloodstream, potentially blocking blood flow or damaging organs like the brain, lungs, kidneys, and spleen. Serious complications include:

  • Sepsis: An extreme, life-threatening response to infection.
  • Heart valve damage.
  • Heart failure.
  • Arrhythmia: Irregular heart rate or rhythm.

Diagnosis

Health care providers diagnose endocarditis by reviewing your medical history, performing a physical exam, and ordering diagnostic tests, which may include blood tests to detect infection, chest x-rays, and heart imaging tests.

Treatment

Prompt treatment is essential and may include:

  • Medicines: Intravenous antibiotics for bacterial infections or antifungal medicine for fungal infections.
  • Heart surgery: To repair or replace damaged valves and tissue or remove infected areas.
  • Dental care: To reduce the bacterial load in the mouth.

Prevention

If you are at higher risk, you can reduce your chances of developing endocarditis by maintaining excellent dental hygiene, attending regular dental exams, and practicing heart-healthy habits. Individuals at the highest risk for bacterial endocarditis may require antibiotics before certain medical or dental procedures; consult your provider to determine if this applies to you.

Frequently Asked Questions

Endocarditis symptoms can be subtle and develop slowly,
Source: MedlinePlus, National Library of Medicine

MedlinePlus brings together authoritative health information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), and other government agencies and health-related organizations.

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