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Lyme Disease
Reviewed by Medicinsk Expert•Last updated: 2026-10-22•Infections

Lyme Disease

Lyme disease is a bacterial infection transmitted through the bite of an infected blacklegged tick, requiring prompt treatment to prevent long-term complications.

What is Lyme disease?

Lyme disease is a bacterial infection transmitted by the bite of an infected tick. Early symptoms often include a rash, fever, headache, and fatigue. If left untreated, the infection can spread to the joints, heart, and nervous system. Prompt treatment is essential for a quick recovery.

Causes and Risk Factors

In the United States, Lyme disease is usually caused by the bacterium Borrelia burgdorferi, which is spread by blacklegged (deer) ticks. These ticks are primarily found in the:

  • Northeast
  • Mid-Atlantic
  • Upper Midwest
  • Pacific coast (especially northern California)

Ticks can attach to any part of the body, often in hard-to-see areas like the groin, armpits, and scalp. Typically, a tick must be attached for more than 24 hours to transmit the bacterium. While most bites occur during warmer months (April–September), they can happen at any time if temperatures are high enough.

Symptoms

Early symptoms appear 3 to 30 days after a bite and include:

  • Erythema migrans (EM): A red rash that often expands over several days. It may feel warm and sometimes resembles a "bull's-eye."
  • Fever and chills
  • Headache and fatigue
  • Muscle and joint aches
  • Swollen lymph nodes

If untreated, the infection may cause:

  • Severe headaches and neck stiffness
  • Additional EM rashes
  • Facial palsy (drooping on one or both sides of the face)
  • Arthritis with severe joint pain and swelling
  • Heart palpitations or irregular heartbeat (Lyme carditis)
  • Dizziness or shortness of breath
  • Inflammation of the brain and spinal cord
  • Nerve pain, numbness, or tingling in the hands or feet

Diagnosis and Treatment

Diagnosis is based on symptoms, potential exposure to ticks, and lab tests. Because antibodies can take weeks to develop, initial tests may be negative even if an infection is present, necessitating follow-up testing.

Lyme disease is treated with antibiotics. Some patients may experience post-treatment Lyme disease syndrome (PTLDS), characterized by lingering pain, fatigue, or difficulty thinking. There is no proven treatment for PTLDS, but symptoms can be managed with guidance from a healthcare provider.

Prevention

To reduce the risk of Lyme disease:

  • Avoid wooded, brushy, or grassy areas; walk in the center of trails.
  • Use EPA-registered insect repellents containing DEET, picaridin, IR3535, oil of lemon eucalyptus, or para-menthane-diol.
  • Treat clothing and gear with 0.5% permethrin.
  • Wear light-colored, protective clothing (long sleeves and pants tucked into socks).
  • Perform daily tick checks on yourself, children, and pets.
  • Shower and dry clothes at high temperatures after outdoor activities.

Frequently Asked Questions

It is crucial to remove the tick as soon as you find it. The risk of transmission increases significantly after the tick has been attached for 36 to 48 hours. Using fine-tipped tweezers, grasp the tick as close to the skin's surface as possible and pull upward with steady, even pressure. Do not twist or jerk the tick, and avoid using heat, petroleum jelly, or nail polish to remove it. After removal, wash the area with soap and water and monitor the site for a rash.
Yes, ticks often attach in hard-to-see areas such as the scalp, groin, armpits, and behind the knees. To check these areas, use a mirror to inspect your scalp and the nape of your neck, and ask a partner or family member to help check your back and groin. Perform a full-body check after spending time in wooded or grassy areas, paying special attention to these hidden spots. Showering within two hours of coming inside may help wash off unattached ticks and provide an opportunity to check your body.
If you find a tick bite, you should still monitor the area and your body for symptoms for at least 30 days. The characteristic erythema migrans rash appears in about 70 to 80 percent of infected persons, but not everyone develops it. If you develop a fever, headache, fatigue, or joint aches after a tick bite, contact your healthcare provider immediately. Do not wait for a rash to appear before seeking medical advice if you have other symptoms or if the tick was attached for more than 24 hours.
Most people can continue their normal activities, including driving and working, while taking antibiotics for early Lyme disease. However, if you experience significant fatigue, dizziness, or cognitive difficulties (sometimes called "brain fog") as side effects of the medication or the infection itself, you should avoid driving or operating heavy machinery until these symptoms subside. Always follow your healthcare provider's specific instructions regarding activity levels and return to work.
Source: MedlinePlus, National Library of Medicine

MedlinePlus brings together authoritative health information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), and other government agencies and health-related organizations.

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