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Syphilis
Reviewed by Medicinsk Expert•Last updated: 2026-10-22•Sexual Health Issues

Syphilis

Syphilis is a bacterial sexually transmitted infection that can cause serious health complications if left untreated but is easily cured with antibiotics in its early stages.

Overview

Syphilis is a sexually transmitted infection (STI) caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy.

Symptoms

The early stage of syphilis usually causes a single, small, painless sore. Sometimes it causes swelling in nearby lymph nodes. If you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. Many people do not notice symptoms for years, and symptoms can go away and come back.

Health Risks

The sores caused by syphilis make it easier to get or give someone HIV during sex. If you are pregnant, syphilis can cause complications, or you could lose your baby. In rare cases, syphilis causes serious health problems and even death.

Treatment & Prevention

Syphilis is easy to cure with antibiotics if you catch it early. Correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. If you or your partner is allergic to latex, you can use polyurethane condoms. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex.

Frequently Asked Questions

Syphilis diagnosis uses two types of tests: treponemal (such as FTA-ABS or TP-PA) and nontreponemal (such as RPR or VDRL). Treponemal antibodies typically remain positive for life regardless of successful treatment. To confirm a cure or detect reinfection, clinicians track nontreponemal titers (RPR/VDRL), which reflect active infection. A fourfold drop in titers (for example, from 1:32 down to 1:8) within 6 to 12 months signifies successful treatment.
The Jarisch-Herxheimer reaction is an acute inflammatory response that occurs in up to 50 percent of patients
Source: MedlinePlus, National Library of Medicine

MedlinePlus brings together authoritative health information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), and other government agencies and health-related organizations.

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