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Bilirubin in Urine
Reviewed by Medicinsk Expert•Last updated: 2026-10-22•Lab Tests

Bilirubin in Urine

A bilirubin in urine test detects the presence of bilirubin, which can serve as an early indicator of liver or bile duct conditions.

What is a bilirubin in urine test?

A bilirubin in urine test measures the levels of bilirubin in your urine. Normally, bilirubin is not found in urine. If it is present, a condition known as bilirubinuria, it may be an early sign of a liver condition. Bilirubin is a yellow substance produced during the breakdown of red blood cells. A healthy liver processes bilirubin into bile; however, if there is a problem with the liver or bile ducts, bilirubin can build up in the blood and spill into the urine.

What is it used for?

This test is often part of a urinalysis, which checks your general health and the status of your urinary tract. It is used to help diagnose liver problems and various other medical conditions.

Why do I need a bilirubin in urine test?

Your provider may order this test during a routine checkup or if you exhibit symptoms of liver, gallbladder, or bile duct issues, such as:

  • Nausea and vomiting
  • Lack of appetite
  • Fatigue and weakness
  • Jaundice (yellowing of skin and eyes)
  • Abdominal swelling or pain
  • Swelling in ankles and legs
  • Dark-colored urine or light-colored stool
  • Frequent itching

Because bilirubin in urine can appear before other symptoms, it may be ordered for those at high risk for liver damage, including individuals with a family history of liver disease, alcohol use disorder, obesity, diabetes, hepatitis, or those taking medications that can cause liver damage.

What happens during a bilirubin in urine test?

You will need to provide a urine sample. A health care professional will provide a cleansing wipe, a container, and instructions for the "clean catch" method to ensure the sample is not contaminated by germs from your skin.

Frequently Asked Questions

Yes. Bilirubin may not appear in urine until the liver’s excretory capacity is significantly impaired. Normal urine bilirubin does not rule out mild or early liver disease; serum liver enzymes and imaging are also needed for a comprehensive assessment.
The test involves collecting a mid‑stream urine sample in a sterile container. The sample is then analyzed in a lab using a dipstick or spectrophotometric method. You may be asked to fast or avoid certain medications that can affect bilirubin levels before the test.
bilirubinuria test can detect early bile duct obstruction or hepatocellular injury before serum bilirubin rises. It is often used in patients with subtle symptoms or risk factors (e.g., alcohol use, medication exposure) to catch liver damage early.
Symptoms such as dark‑colored urine, pale stools, unexplained jaundice, abdominal pain or swelling, or a history of liver‑related risk factors (e.g., hepatitis, heavy alcohol use, obesity) are indications for a bilirubinuria test.
Source: MedlinePlus, National Library of Medicine

MedlinePlus brings together authoritative health information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), and other government agencies and health-related organizations.

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