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How to Prepare for a Lab Test
Reviewed by Medicinsk Expert•Last updated: 2026-10-22•Lab Tests

How to Prepare for a Lab Test

Proper preparation for lab tests is essential for accurate results, and following your provider's specific instructions is the best way to ensure reliable data.

How do I prepare for a lab test?

Lab tests analyze blood, urine, or tissue to help diagnose, screen for, or monitor diseases. To ensure your results are accurate, you must:

  • Follow all instructions provided by your health care professional.
  • Be honest if you did not follow instructions exactly, as even minor deviations can affect results.
  • Inform your provider about all medications, vitamins, and supplements you are taking.

Common preparation steps

The most common requirement is fasting, which means not eating or drinking anything except water for a specified period (often overnight). This prevents nutrients from food from interfering with your blood chemistry. Other preparations may include:

  • Avoiding specific foods, drinks (like alcohol or herbal tea), or smoking.
  • Avoiding strenuous exercise or sexual activity.
  • Adjusting medication schedules only if directed by your provider.
  • Drinking extra water to keep veins hydrated for blood draws.

Tests requiring special preparation

Some tests have unique requirements:

  • Fasting tests: Blood glucose, cholesterol, triglycerides, and calcitonin tests.
  • Dietary/Activity restrictions: Creatinine (avoiding cooked meats), 5-HIAA (avoiding foods like avocados, bananas, and walnuts), and Pap smears (avoiding douching, tampons, or sex for 24–48 hours).
  • Rest: Cortisol tests may require resting before the sample is taken.

Always clarify your preparation instructions with your provider before the day of your test to ensure you understand exactly what is required.

Frequently Asked Questions

Most medications can be taken with a small sip of water, but some labs ask you to hold certain drugs (e.g., insulin, blood thinners, thyroid meds) because they can alter results. Always ask your provider or the lab’s instructions before skipping any dose.
Only tests that measure glucose, lipids (cholesterol, triglycerides), certain hormones (e.g., cortisol) or specific tumor markers require fasting. Your provider will tell you which tests need a fast; if you’re unsure, call the lab or office to confirm.
Drink plenty of water (8‑10 ounces) before bedtime and again when you wake up; staying hydrated helps keep veins plump. A light, low‑fat snack (e.g., a piece of fruit) the evening before is usually fine unless the test specifically requires an overnight fast without any food.
void foods high in serotonin that can falsely elevate 5‑HIAA, such as bananas, avocados, pineapples, walnuts, and kiwis, for at least 24 hours before collecting the urine. Also skip any over‑the‑counter cough syrups or cold medicines that contain serotonin‑affecting ingredients.
Source: MedlinePlus, National Library of Medicine

MedlinePlus brings together authoritative health information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), and other government agencies and health-related organizations.

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