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Kaposi Sarcoma
Reviewed by Medicinsk Expert•Last updated: 2026-10-22•Skin Hair Nails

Kaposi Sarcoma

Kaposi sarcoma is a type of cancer that causes lesions to grow in the skin, lymph nodes, mucous membranes, and other organs.

What is Kaposi sarcoma?

Kaposi sarcoma, sometimes called KS, is a type of cancer. It causes lesions (abnormal tissue) to grow in different parts of the body, including:

  • The skin
  • Lymph nodes
  • Mucous membranes (the lining of the mouth, nose, and throat)
  • Other organs

These lesions are usually red or purple. They are made of cancer cells, new blood vessels, and blood cells. The lesions may begin in more than one place in the body at the same time. This makes Kaposi sarcoma different from other cancers.

What causes Kaposi sarcoma and who is more likely to develop it?

Kaposi sarcoma is caused by infection with human herpesvirus-8 (HHV-8). This virus is also called Kaposi sarcoma-associated herpesvirus (KSHV). Most people infected with this virus don't get Kaposi sarcoma. But certain people who get this virus are more likely to develop one of the types of Kaposi sarcoma:

  • People with weakened immune systems due to HIV can develop epidemic (HIV-associated) Kaposi sarcoma.
  • People with weakened immune systems due to medicines they need to take after an organ transplant can develop iatrogenic (transplant-related) Kaposi sarcoma.
  • Older men of Mediterranean or Eastern European Jewish heritage can develop classic Kaposi sarcoma.
  • Young men in Africa can develop endemic (African) Kaposi sarcoma.

What are the symptoms of Kaposi sarcoma?

Kaposi sarcoma usually starts out as one or more red, purple, or brown skin lesions on the legs and feet. They are most often on the ankles or soles of the feet. Over time, lesions may form in other parts of the body. The lesions may not cause symptoms. But sometimes the lesions can cause problems, especially as you get more of them and they grow bigger. For example:

  • Pressure from the lesions may block the flow of lymph and blood in the legs and cause painful swelling
  • If lesions grow in your stomach or intestines, they can bleed and may cause abdominal (belly) pain and diarrhea
  • Lesions in the lungs can also bleed and may cause shortness of breath

How is Kaposi sarcoma diagnosed?

To find out whether you have Kaposi sarcoma, your health care provider:

  • Will ask about your medical and family history
  • Will do a physical exam
  • May order a chest x-ray to look for Kaposi sarcoma in the lungs
  • May do a biopsy to check for Kaposi sarcoma lesions in the skin
  • May do an endoscopy to check for Kaposi sarcoma in the stomach and intestines
  • May do a bronchoscopy to check for Kaposi sarcoma in the lungs

If you do have Kaposi sarcoma, you will likely need blood and imaging tests to find out if the cancer has spread to other parts of the body.

What are the treatments for Kaposi sarcoma?

Which treatment(s) you get will depend on:

  • The type of Kaposi sarcoma you have
  • How many lesions you have and where in the body they are
  • What kinds of problems the lesions are causing
  • Your overall health

For people who have epidemic (HIV-associated) Kaposi sarcoma, taking HIV medicines may be enough to treat the Kaposi sarcoma. For people who have iatrogenic (transplant-related) Kaposi sarcoma, changing the dose of the medicines or switching medicines may be helpful. But some people with these types of Kaposi sarcoma will need additional treatment.

The treatment options for Kaposi sarcoma may include:

  • Radiation therapy
  • Surgery
  • Cryosurgery, a treatment that uses an instrument to freeze and destroy abnormal tissue
  • Chemotherapy
  • Immunotherapy

Frequently Asked Questions

The long-term outlook for Kaposi sarcoma varies greatly depending on the type, the patient's immune status, and the extent of the disease. For classic Kaposi sarcoma, it often progresses slowly. For HIV-associated Kaposi sarcoma, effective HIV treatment can significantly improve the prognosis. Regular follow-up with your healthcare provider is essential to monitor for new lesions, assess treatment effectiveness, and manage any side effects or complications. This often includes routine skin exams and sometimes imaging or endoscopy to check for internal involvement.
The earliest signs of Kaposi sarcoma are typically new red, purple, or brown spots or patches on the skin, often starting on the legs, feet, or ankles. These lesions may be flat or slightly raised and usually do not itch or cause pain. If you are at higher risk, regularly check your skin for any new or changing lesions, and report them to your doctor promptly.
Treatment for Kaposi sarcoma depends on the type, extent, and location of the lesions, as well as the patient's overall health. Common treatments include chemotherapy, radiation therapy, cryotherapy (freezing), or surgical removal for skin lesions. For HIV-associated Kaposi sarcoma, highly active antiretroviral therapy (HAART) is crucial as it strengthens the immune system, often leading to lesion regression. The main goals are to control the growth of lesions, alleviate symptoms, and improve quality of life.
Kaposi sarcoma lesions can appear in multiple places at the same time and can spread beyond the skin to internal organs like the lymph nodes, lungs, or gastrointestinal tract. The risk of internal spread is higher in people with weakened immune systems, such as those with HIV/AIDS or organ transplant recipients. Monitoring for symptoms like swelling, shortness of breath, or digestive issues is important.
Source: MedlinePlus, National Library of Medicine

MedlinePlus brings together authoritative health information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), and other government agencies and health-related organizations.

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