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Leishmaniasis
Reviewed by Medicinsk Expert•Last updated: 2026-10-22•Skin Hair Nails

Leishmaniasis

Leishmaniasis is a parasitic disease transmitted by sand flies that can affect either the skin or internal organs.

Overview

Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. There are several different forms of the disease:

  • Cutaneous: The most common form, which causes skin sores.
  • Visceral: Affects internal organs such as the spleen, liver, and bone marrow. Symptoms include fever, weight loss, and an enlarged spleen and liver.

Geographic Distribution

Leishmaniasis is found in parts of about 88 countries, mostly in the tropics and subtropics. While it is very unlikely to contract this disease in the United States, travelers should be aware of the risk when visiting the Middle East, parts of Central America, South America, Asia, Africa, or southern Europe.

Treatment and Prevention

Treatment involves medicines that contain antimony (a type of metal) or strong antibiotics. The best way to prevent the disease is to protect yourself from sand fly bites:

  • Stay indoors from dusk to dawn, when sand flies are the most active.
  • Wear long pants and long-sleeved shirts when outside.
  • Use insect repellent and bed nets as needed.

Frequently Asked Questions

Pentavalent antimonials (e.g., sodium stibogluconate, meglumine antimoniate) can cause nausea, vomiting, muscle cramps, elevated liver enzymes, and cardiac arrhythmias. Monitoring labs weekly, staying hydrated, taking anti‑emetics, and adjusting the dose under physician supervision help reduce complications.
Relapse is uncommon after successful treatment of cutaneous disease but can occur, especially in immunocompromised patients or with certain Leishmania species. Inform your clinician of any new skin lesions or systemic symptoms; a repeat evaluation may be warranted.
Cutaneous lesions typically develop 2 weeks to several months after the bite. If you notice a persistent papule, nodule, or ulcer that enlarges, becomes painful, or fails to heal within 4 weeks, seek medical attention for diagnosis and early treatment.
Visceral leishmaniasis is usually confirmed with blood tests (serology, PCR, or bone‑marrow aspirate). Cutaneous disease often requires a skin biopsy or a swab for PCR to identify the parasite, because serology is less reliable for skin‑limited infection.
Source: MedlinePlus, National Library of Medicine

MedlinePlus brings together authoritative health information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), and other government agencies and health-related organizations.

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