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Colorectal Cancer Screening Tests
Reviewed by Medicinsk Expert•Last updated: 2026-10-22•Lab Tests

Colorectal Cancer Screening Tests

Colorectal cancer screening tests are used to detect cancer early or prevent it by identifying and removing precancerous polyps in the colon or rectum.

Overview

Colorectal cancer often begins as colorectal polyps—abnormal growths that are usually benign but can become cancerous over time. Screening allows providers to find and remove these polyps or detect cancer at an early, more treatable stage.

Screening Options

Visual Exams

  • Colonoscopy: Examines the entire colon and rectum. Requires bowel prep and sedation. Polyps can be removed or biopsied during the procedure.
  • Sigmoidoscopy: Examines the rectum and lower colon. Usually requires less prep than a colonoscopy and no sedation.
  • Virtual Colonoscopy (CT colonography): Uses X-rays and a computer to create 3D images of the colon. Requires bowel prep but no sedation.

Stool Tests

  • Fecal Immunochemical Test (FIT): Checks for hidden blood in the stool.
  • Guaiac Smear Test (gFOBT): Uses a chemical reaction to detect hidden blood; requires specific dietary restrictions before testing.
  • Stool DNA (FIT-DNA) Test: Checks for genetic changes in the stool that may indicate polyps or cancer.

Why do I need screening?

If you are at average risk, screening is generally recommended starting at age 45. You may need to start earlier or be screened more frequently if you have risk factors such as a family history of colorectal or ovarian cancer, inflammatory bowel disease (ulcerative colitis or Crohn's disease), obesity, smoking, or alcohol misuse.

What do the results mean?

Abnormal results on stool tests do not confirm cancer but indicate the need for a follow-up colonoscopy. If polyps are found during a visual exam, they are typically removed and sent to a lab for testing. If your results are abnormal, your provider will discuss the next steps for diagnosis and treatment.

Frequently Asked Questions

For average-risk adults, the Fecal Immunochemical Test (FIT) is typically recommended annually. The Stool DNA test (FIT-DNA) is usually performed every one to three years, depending on your provider's guidance and current guidelines. It is crucial to adhere to these intervals because stool tests only detect markers present at the time of collection; they do not visualize the colon, so missing a window could allow a polyp to grow undetected. What dietary restrictions apply before a Guaiac Smear Test (gFOBT) compared to a FIT test?::Before a Guaiac Smear Test (gFOBT), you must avoid red meat, raw or undercooked vegetables, and certain fruits like cantaloupe and turnips for three days prior to the test, as these can cause false positives. In contrast, the Fecal Immunochemical Test (FIT) is more specific to human blood and generally does not require dietary restrictions, making it more convenient for many patients. Always confirm specific instructions with your lab, as protocols can vary slightly. What happens if a polyp is found during a colonoscopy, and how soon will I know the results?::If a polyp is found, the gastroenterologist will usually remove it immediately using a snare and send the tissue to a pathology lab for analysis. You will typically receive the biopsy results within one to two weeks. If the polyp is benign, your doctor will schedule your next screening based on the size and type of the polyp, which may be sooner than the standard ten-year interval. If cancer is found, a multidisciplinary team will discuss treatment options with you promptly. Can I eat or drink normally after a colonoscopy, or are there specific restrictions?::Most people can resume a normal diet immediately after a colonoscopy, although you may feel bloated or gassy due to the air used during the procedure. It is advisable to start with light, easily digestible foods and stay well-hydrated. If you experienced significant sedation, you should not drive or operate heavy machinery for 24 hours. Contact your provider immediately if you experience severe abdominal pain, fever, or heavy rectal bleeding after the procedure.
Source: MedlinePlus, National Library of Medicine

MedlinePlus brings together authoritative health information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), and other government agencies and health-related organizations.

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